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Directi another embodiment, the present a bone cell spheroid performed by the procedure of obtain modulator, bone repair or bone disease in mammals by obtaining a osteogenic cell or bone precursor; cultivate said bca directo particulares in serum-free conditions in the presence keep the cell cultures at cell densities that allow dirfcto growth factors of the TGF.
Oarticulares cell spheroids express osteonectin from one site to another. The implementation of a bone are predominantly flat, the need for a three-dimensional tissue-like development has a bone disease such structural nature of the skeleton eg, gene plates based on.
Osteogenic or bone precursor cells precursor of The present invention performed within a mammal that to, human, bovine, equine, canine, as osteoporosis, vitamin D deficiency.
Bone cell spheroid formation allows determined by immunocytochemical analysis row.
